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目的探讨孕妇血清中胰岛素样生长因子-Ⅰ(Insulin-Like Growth FactorⅠ,IGF-I)水平与妊娠期高血压疾病发生、发展及预后的相关性。方法于分娩前分别抽取16例正常妊娠孕妇(对照组)、48例妊娠期高血压疾病孕妇(实验组)肘静脉血5毫升,离心后共获得血清64份,用ELISA法测血清中IGF-I水平;记录新生儿出生体重。结果实验组血清中IGF-I平均浓度明显低于正常对照组(P<0.05);不同程度妊娠期高血压疾病孕妇血清中IGF-I浓度之间存在差异且具有显著性(P<0.05);实验组新生儿出生体重明显低于正常对照组(P<0.05);实验组和正常对照组各组孕妇血清中IGF-I浓度与新生儿出生体重成正相关(P<0.05)。结论血清中IGF-I浓度与妊娠期高血压疾病的发生、发展及预后有关,可做为诊断妊娠期高血压疾病的一个新的辅助指标,并为该病的治疗提供新途径。
Objective To investigate the correlation between serum levels of insulin-like growth factor-I (IGF-I) and the occurrence, development and prognosis of hypertensive disorder complicating pregnancy. Methods Sixteen pregnant women (control group) and 48 pregnant women (experimental group) with elbow venous blood from pregnancy were collected before delivery. 5 mL of elbow venous blood was obtained from pregnant women with experimental hypertension. 64 serum samples were obtained after centrifugation. The levels of IGF- I level; record newborn birth weight. Results The serum IGF-I concentration in the experimental group was significantly lower than that in the normal control group (P <0.05). The IGF-I levels in pregnant women with different stages of pregnancy-induced hypertension were significantly different (P <0.05). The birth weight of neonates in the experimental group was significantly lower than that of the normal control group (P <0.05). IGF-I levels in the serum of the experimental group and the normal control group were positively correlated with the birth weight of newborns (P <0.05). Conclusion Serum IGF-I levels are associated with the occurrence, development and prognosis of hypertensive disorder complicating pregnancy. It may serve as a new auxiliary indicator for the diagnosis of hypertensive disorders in pregnancy and provide a new way for the treatment of this disease.