论文部分内容阅读
变态反应性疾病和风湿性疾病是儿童时期常见的免疫系统紊乱性疾病,其特点为发病率逐年上升,病程长,易反复,不利于患儿病情恢复,明显影响疾病的预后。既往经典的Th1/Th2理论认为:Th1介导的风湿性疾病和Th2介导的变态反应性疾病在免疫机制及发病情况上相互补充,从而出现体内原本失衡的T细胞亚群达到新的平衡,改善了患儿的预后。而近年的研究发现对该理论提出了新的挑战,认为变态反应性疾病和风湿性疾病无论在发病机制还是在临床表现方面均互为危险因素。因此,阐明两者的关系有利于指导临床的诊疗和预后判断。本文拟结合国内外研究进展,把儿童变态反应性疾病对风湿性疾病的影响进展做一阐述。
Allergic diseases and rheumatic diseases are common disorders of the immune system in childhood. They are characterized by a rising incidence rate, long duration and easily repeated diseases, which are not conducive to the recovery of children’s condition and significantly affect the prognosis of the disease. Previous classic Th1 / Th2 theory that: Th1-mediated rheumatic diseases and Th2-mediated allergic diseases complement each other in the immune mechanism and incidence, resulting in the body had unbalanced T cell subsets to a new balance, Improve the prognosis of children. In recent years, however, research has found new challenges to this theory, arguing that allergic and rheumatic diseases are risk factors for each other both in pathogenesis and in clinical manifestations. Therefore, to clarify the relationship between the two is conducive to guiding clinical diagnosis and prognosis. This article intends to combine the research progress at home and abroad, to make an elaboration of the progress of children’s allergic diseases on rheumatic diseases.