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本文应用国产和进口两种布比卡因(浓度均为0.5%)进行上腹部手术硬膜外阻滞共76例,其中国产组43例,进口组33例。对两药显效时间、作用完全时间、一次剂量维持时间和镇痛持续时间进行比较,均无明显差别,加入1∶20万肾上腺素,上述各时间亦大多未见显著延长。两药在0.5%浓度时镇痛、肌松效果均颇满意,未见毒性反应,但麻醉后切皮前血压下降20%以上者比利多卡因增多,提示交感神经节前纤维更易受布比卡因阻滞。
In this paper, 76 cases of epidural anesthesia for upper abdomen surgery were treated with both domestic and imported bupivacaine (concentration 0.5%), of which 43 cases were in the domestic group and 33 cases were in the import group. The two drugs markedly effective time, the role of complete time, a dose of time and duration of analgesia were no significant difference, adding 1: 200000 epinephrine, most of the above time also have not been significantly prolonged. Analgesic effect of both drugs at 0.5% concentration, muscle relaxants were satisfactory, no toxic reaction, but after anesthesia before the skin pressure drop more than 20% lidocaine increased, suggesting that preganglionic sympathetic preganglionic fibers more susceptible to cloth than Caffeine block.