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目的总结SD大鼠的自发性肿瘤的发生情况,为检测农药、食品、药品等化学品的致癌性及探讨其作用机制提供基础数据。方法将本实验室最近几年来完成的6个致癌试验的800只对照组大鼠(雌雄各半)的肿瘤发生情况进行汇总并分析。结果实际检测783只大鼠(雌性392只,雄性391只),其中患瘤动物504只(雌性331只,雄性173只),共检出1058例肿瘤,肿瘤总发生率为64.37%(雌性84.44%,雄性44.25%),大鼠平均肿瘤数为2.09例/只(雌性2.46,雄性1.4);大鼠单发和多发肿瘤发生率分别为30.90%和33.46%(雌性分别为30.35%和54.08%,雄性分别为31.45%和12.79%),患瘤动物最高肿瘤数为9例。在所检出的肿瘤大多为良性肿瘤(87.01%),以乳腺纤维腺瘤(31.67%)和垂体腺瘤(27.84%)最为常见;肿瘤多发生于乳腺、垂体、软组织、皮肤等脏器或组织。结论本实验室选用的SD大鼠自发性肿瘤发生率较高,且多为良性肿瘤,以乳腺纤维腺瘤和垂体腺瘤最为多见。
Objective To summarize the occurrence of spontaneous tumors in SD rats and provide basic data for the detection of carcinogenicity of chemicals such as pesticides, foodstuffs and pharmaceuticals and to explore their mechanism of action. Methods Tumor incidences of 800 control rats (half male and half female) in six carcinogenicity trials completed in our laboratory in recent years were summarized and analyzed. Results A total of 783 rats (392 females and 391 males) were detected. Among them, 504 (331 females and 173 males) were found in this study. A total of 1058 tumors were detected, with a total tumor incidence of 64.37% (female 84.44 %, Male 44.25%). The average number of tumors in rats was 2.09 cases per female (2.46 for males and 1.4 for males). The rates of single and multiple tumors in rats were 30.90% and 33.46% (female, 30.35% and 54.08% And 31.45% in males and 12.79% in males, respectively), and the highest number of tumor-bearing animals was 9. Most of the tumors detected were benign (87.01%), the most common were fibroadenoma of the breast (31.67%) and pituitary adenoma (27.84%). Tumors mostly occurred in the tissues of the breast, pituitary, soft tissue and skin or organization. Conclusion The spontaneous tumor incidence of SD rats used in our laboratory is high, and most of them are benign tumors, the most common being fibroadenoma of the breast and pituitary adenoma.