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目的建立适合南宁地区的羊水AFP检测的参考值范围和质控体系。方法运用酶联免疫吸附法分别对南宁1263例17~22周孕妇的羊水AFP进行检测,采用对数正态转换方法建立各孕周的正常参考值和中位值。结果孕17周羊水AFP浓度参考值(5432~31568ug/L),2.5MOM为39460ug/L;孕18周羊水AFP浓度参考值(4492~26334ug/L),2.5MOM为32910ug/L;孕19周羊水AFP浓度参考值(4964~22494ug/L),2.5MOM为28117ug/L;孕20周羊水AFP浓度参考值(4064~21590ug/L),2.5MOM为23530ug/L;孕21周羊水AFP浓度参考值(3011~18317ug/L),2.5MOM为19102ug/L;孕22周羊水AFP浓度参考值(2617~17854ug/L),2.5MOM为18168ug/L。结论由于受多种因素的影响有必要建立适合本地区的羊水AFP参考值。
Objective To establish a reference value range and quality control system for detecting amniotic fluid AFP in Nanning. Methods The amniotic fluid AFP of 1263 pregnant women aged 17-22 weeks in Nanning were detected by enzyme-linked immunosorbent assay (ELISA). The normal reference value and median of each gestational week were established by logarithmic normal conversion method. Results The reference value of amniotic fluid AFP (5432 ~ 31568ug / L) and 39460ug / L of pregnant women were 17 weeks pregnant. The reference value of amniotic fluid AFP (4492 ~ 26334ug / L) Amniotic fluid AFP concentration reference value (4964 ~ 22494ug / L), 2.5MOM was 28117ug / L; pregnant 20 weeks amniotic fluid AFP concentration reference value (4064 ~ 21590ug / L), 2.5MOM was 23530ug / L; (3011 ~ 18317ug / L), 2.5MOM was 19102ug / L; the reference value of amniotic fluid AFP concentration was 2617 ~ 17854ug / L in pregnant week 22 and 18168ug / L in 2.5MOM. Conclusion Due to many factors, it is necessary to establish the AFP reference value for amniotic fluid in this area.