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本文报道1989年8月至1990年10月间对10317名健康婴儿随机分组,分别于2、4、6月龄接种b型流感杆菌荚膜多糖-破伤风类毒素结合菌苗(PRP-T)(10μg/0.5ml)或重组乙型肝炎疫苗(R-HBV)(10μg/0.5ml).两者均为右侧大腿肌肉注射,同时于左侧大腿肌肉内接种DTP,并口服脊髓灰质炎疫苗(OPV).每剂接种后观察30分钟,并由其父母填写6、24、48和72小时时的反应记录.135名婴儿于2、4、6、7、12和15月龄时采集血标本,以酶免疫法(EIA)测抗-HBs,ELISA测破伤风和白喉抗体,放射免疫法(RIA)测Hib多糖抗体.
This article reports from August 1989 to October 1990 10317 healthy infants were randomly divided into groups, at the age of 2, 4, 6 months inoculated with influenza B capsular polysaccharide - tetanus toxoid conjugate vaccine (PRP-T) (10 μg / 0.5 ml) or recombinant hepatitis B vaccine (R-HBV) (10 μg / 0.5 ml) Both were intramuscularly injected into the right thigh while DTP was intramuscularly administered to the left thigh and oral poliomyelitis vaccine (OPV) 30 minutes after each dose inoculation, and responses recorded at 6,24,48 and 72 hours by their parents Recorded blood from 135 infants at 2, 4, 6, 7, 12 and 15 months of age The specimens were tested for anti-HBs by enzyme-linked immunosorbent assay (EIA), tetanus and diphtheria antibodies by ELISA, and Hib polysaccharide antibodies by radioimmunoassay (RIA).