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长期口服激素治疗哮喘会引起严重的副作用。有资料表明,非激素类抗炎药物——金盐制剂,能够调节哮喘患者机体免疫应答及抑制气道炎症反应,从而减轻临床哮喘症状,减少激素用量。拟用醋硫匍金(Auranofin)治疗激素依赖性哮喘患者,并观察其临床症状、肺功能及对激素用量的影响。患者和方法哮喘患者32例,随机分为对照组和试验组。所有患者平均年龄52.4(28～72)岁。其中男17例、女15例,均具有发作性咳嗽、呼吸困难、喘鸣等典型哮喘症状,病史2～40年不等。对照组FEV_1基础值平均占预计值的59.7％,试验组为59.8％.两组患者均长期口服激素,时间至少1年,而且每天口服强的松均在2.5mg以上。试验组在试
Long-term oral hormonal treatment of asthma can cause serious side effects. Data show that the non-hormonal anti-inflammatory drugs - gold salt preparations, can regulate the body’s immune response in asthma and suppress airway inflammation, thereby reducing the clinical symptoms of asthma and reduce the amount of hormones. We plan to treat patients with hormone-dependent asthma with Auranofin and observe its clinical symptoms, lung function and hormone dosage. Patients and Methods Asthma patients 32 cases were randomly divided into control group and experimental group. The average age of all patients was 52.4 (28-72) years. There were 17 males and 15 females with typical asthma symptoms such as episodes of cough, dyspnea and wheezing, with a history of 2 to 40 years. In the control group, the basal value of FEV_1 accounted for 59.7% of the predicted value on average, and the experimental group was 59.8%. Both groups had long-term oral administration of hormones for at least 1 year, and oral prednisone was 2.5mg daily. Test group in the trial