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目的研究不同抗癫痫类药物对三叉神经痛的干预效果。方法选取2013年5月—2015年10月收治的136例三叉神经痛患者,均接受抗癫痫药物治疗。采用抽签随机法分为三组,其中采用卡马西平治疗46例,采用拉莫三嗪治疗45例,采用加巴喷丁治疗45例,均持续用药治疗6周。观察3组治疗效果和不良反应症状。结果卡马西平组治疗显效28例、有效13例、无效5例,总有效率89.13%;拉莫三嗪组显效21例、有效11例、无效13例,总有效率71.11%;加巴喷丁组显效19例、有效10例、无效16例,总有效率64.44%,卡马西平组组疗效明显优于拉莫三嗪组、加巴喷丁组(均P<0.05);卡马西平组不良反应率17.39%高于拉莫三嗪组6.67%、加巴喷丁组8.89%,三组不良反应率差异无统计学意义(P>0.05)。结论卡马西平治疗三叉神经痛效果优于拉莫三嗪和加巴喷丁,但不良反应症状较多;拉莫三嗪和加巴喷丁也能有效缓解三叉神经痛症状,药效虽不及卡马西平,但安全性较好。
Objective To study the effects of different antiepileptic drugs on trigeminal neuralgia. Methods A total of 136 patients with trigeminal neuralgia who were admitted to our hospital from May 2013 to October 2015 were treated with antiepileptic drugs. Randomized by lottery were divided into three groups, of which 46 cases were treated with carbamazepine, 45 cases were treated with lamotrigine, and 45 cases were treated with gabapentin, all of which were treated for 6 weeks. Three groups were observed the treatment effect and adverse reaction symptoms. Results Carbamazepine group was effective in 28 cases, effective in 13 cases, ineffective in 5 cases, total effective rate was 89.13%; lamotrigine group in 21 cases, effective in 11 cases, ineffective in 13 cases, total effective rate was 71.11%; gabapentin group was effective 19 cases, effective in 10 cases, ineffective in 16 cases, the total effective rate was 64.44%, carbamazepine group was significantly better than lamotrigine group, gabapentin group (all P <0.05); carbamazepine adverse reaction rate was 17.39% 6.67% higher than the lamotrigine group, and 8.89% of the gabapentin group. There was no significant difference in adverse reaction rate between the three groups (P> 0.05). Conclusion Carbamazepine treatment of trigeminal neuralgia better than lamotrigine and gabapentin, but more adverse reactions; lamotrigine and gabapentin can effectively alleviate the symptoms of trigeminal neuralgia, although less effective than carbamazepine, but safe Sex is better.