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目的 评估血清免疫抑制酸性蛋白 (IAP)与原发性肝癌 (PHC)发生的相关性。方法 应用单向免疫琼脂扩散法检测3 0例PHC患者、3 0例家族成员 (FM)和 3 0例正常健康人 (NS)血清IAP水平。结果 PHC患者血清IAP水平 (85 1± 2 12 ) μg/ml与正常健康人 (2 78± 10 4) μg/ml比较有显著差异 (P <0 0 1) ;FM组 (5 73± 2 2 8) μg/ml与NS组比较有统计学差异 (P <0 0 1)。结论 IAP水平的改变可能与PHC发生相关 ,且IAP检测可被用于PHC易患个体的筛选。
Objective To evaluate the correlation between serum immunosuppressive acid protein (IAP) and the occurrence of primary liver cancer (PHC). Methods Serum IAP levels of 30 patients with PHC, 30 family members (FM) and 30 healthy controls (NS) were detected by one-way immunogold agar diffusion assay. Results The level of serum IAP in PHC patients was significantly higher than that in healthy controls (85 1 ± 2 12) μg / ml vs 2 78 ± 10 4 μg / ml (P <0.01) 8) μg / ml had statistical difference compared with NS group (P <0.01). Conclusion The change of IAP level may be related to the occurrence of PHC, and IAP test can be used for the screening of PHC susceptible individuals.