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磁性铁氧化物纳米粒子(MIONPs)是近几十年发展起来的一种具有磁靶向性的纳米材料,其以良好的磁靶向性、小尺寸效应、生物相容性等特点在生物医学领域具有很好的应用前景,尤其在药剂学领域的应用已经成为一个重要的研究方向。本文在总结近年来国内外有关多功能MIONPs研究成果的基础上,阐述了各种铁氧化物纳米粒子在药剂学领域的应用,主要包括MIONPs的智能载药靶向控释、对特殊药物的靶向负载、降低身体的多药耐药性(MDR)、加强药物治疗效果、载药穿透血脑屏障(BBB)等;并讨论了当前应用中的优点和不足。最后,展望了其在药物、药剂学领域的应用前景并指出了一些亟待解决的问题。
Magnetic iron oxide nanoparticles (MIONPs) are recently developed with a magnetic targeting of nano-materials, which with good magnetic targeting, small size, biocompatibility and other characteristics in the biomedical The field has a good application prospect, especially in the field of pharmacy has become an important research direction. This paper summarizes the research results of multifunctional MIONPs at home and abroad in recent years, and expounds the application of various iron oxide nanoparticles in the field of pharmacy, including the intelligent controlled drug release of MIONPs, the target of special drugs To the load, reduce the body’s multi-drug resistance (MDR), to enhance the drug treatment effect, drug penetration through the blood-brain barrier (BBB), etc .; and discusses the advantages and disadvantages of current applications. Finally, the prospect of its application in the field of medicine and pharmacy is prospected and some problems to be solved are pointed out.