超声波引导下,局部乙醇注射疗法(PEIT)在动物实验已证实其抗肿瘤效果。对Waster 系小白鼠的正常肝用四氯化碳诱发肝硬变,用4-二甲氨基偶氮苯诱发肝癌后,剖腹,局部注射0.2ml 纯乙醇,对注后即刻、3天、7天的病理组织变化作对比研究。鼠的正常肝,在刚注入后不久即有血窦和Disse 腔明显扩大,肝细胞萎缩及一部分肝细胞变性。同时也有血栓的形成。3天后,仍残存肝细胞素的构造,细胞浆呈嗜酸性变性,核消失,肝细胞坏死。7月后,仍残留部分肝细胞素的构造,可是已凝固坏死,并且 Ultrasound-guided local ethanol injection therapy (PEIT) has demonstrated its anti-tumor effect in animal experiments. Liver cirrhosis induced by carbon tetrachloride in normal livers of Waster rats was induced by 4-dimethylaminoazobenzene followed by laparotomy and local injection of 0.2 ml of pure ethanol, immediately after injection, 3 days, and 7 days. The histopathological changes were compared. In the normal liver of rats, the sinusoids and Disse lumens were significantly enlarged shortly after injection, and hepatocytes were atrophied and some hepatocytes were degenerated. There are also thrombosis formations. After 3 days, the structure of hepatocyte remained, and the cytoplasm became eosinophilic, the nuclei disappeared, and the hepatocytes became necrotic. After 7 months, some of the hepatic cell structure remains, but it has coagulated necrosis, and