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目的:探讨乙酰肝素酶(heparanase,HPSE)与人类自然流产的关系及在正常妊娠和自然流产过程中所起的作用。方法:采用免疫荧光法和Western blot检测非意愿性正常妊娠者流产绒毛组织和早期自然流产者流产绒毛中HPSE的表达情况。结果:正常妊娠组的HPSE表达率明显高于自然流产组,差异有统计学意义(P<0.05)。结论:HPSE参与正常妊娠的胚胎植入过程,自然流产的发生可能与HPSE的低表达、胚胎的低植入率有关。
Objective: To investigate the relationship between heparanase (HPSE) and human spontaneous abortion and its role in normal pregnancy and spontaneous abortion. Methods: Immunofluorescence and Western blot were used to detect the expression of HPSE in aborted villi of abortion chorion and early spontaneous abortion in unintended normal pregnancy. Results: The expression of HPSE in normal pregnancy group was significantly higher than that in spontaneous abortion group (P <0.05). Conclusion: HPSE is involved in embryo implantation in normal pregnancy. The occurrence of spontaneous abortion may be related to the low expression of HPSE and the low implantation rate of embryos.