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为研究红霉素（ＥＭ）对兔胆囊（ＧＢ）运动的影响，动物禁食后静脉麻醉，同步记录ＧＢ内压及奥迪氏括约肌（ＳＯ）肌电，静脉注射ＥＭ后ＧＢ运动增强，注药后１０ｓ内出现第１相效应（Ｐｈａｓｅ Ａ），表现为ＧＢ内压升高；注药后 １０ｍｉｎ开始出现第２相效应（Ｐｈａｓｅ Ｂ），主要是ＧＢ位相性收缩增强。 ＥＭ静脉灌注兴奋ＣＢ运动的效应同ＥＭ静脉注射相似。静脉注射阿托品或颈部迷走神经切断后静脉灌注或注射ＥＭ，ＰｈａｓｅＡ依然存在，而Ｐｈａｓｅ Ｂ消灭。结果提示， ＥＭ先后引起ＧＢ内压升高及ＧＢ位相性收缩增强两相效应，其中ＰｈａｓｅＡ可能是ＢＭ 直接兴奋胆道平滑肌上受体实现的，Ｐｈａｓｅ Ｂ是ＥＭ通过兴奋胆碱能神经通路起作用。
In order to study the effect of erythromycin (EM) on gallbladder (GB) movement in rabbits, the rats were anesthetized by fasting, the GB internal pressure and the sphincter of Oddi’s sphincter (SO) The first phase (Phase A) appeared within the first 10 seconds, which showed the increase of internal pressure of GB. The second phase (Phase B) started to appear after 10 minutes of injection, mainly the increase of GB phase contractility. The effect of intravenous infusion of EM on CB motility was similar to that of EM intravenous injection. Intravenous injection of atropine or cervical vagotomy after intravenous infusion or injection of EM, PhaseA still exists, and Phase B eliminated. The results suggested that EM induced two-phase effects of GB internal pressure and GB phase contractility. Phase A may be the direct receptor of BM on biliary smooth muscle. Phase B is EM through the activation of cholinergic nerve pathway.