Catalyzed by zinc bromide,tetrahydrofuran ring can be opened with acyloxyphosphonium bromide generated in situ to afford 4-bromobutyl esters under mild conditio
A potent anxiolytic 4-butyl-α-agarofuran (AF-5) was synthesized from (+)dihydro-carvone. Acid catalyzed hydration of (+)dihydrocarvone and interconversion with