最近,继欧美之后,日本也开始使用咳嗽性哮喘(cough variant asthma,CVA)综合征这一概念,并已引起人们的广泛关注。CVA 一词始用于1982年,它是一种慢性且不伴有喘鸣和呼吸困难的干性咳嗽。由于其具有气道敏感性亢进以及支气管扩张剂可使咳嗽消失的特征,故目前认为它属于变异性哮喘。此外,有些病例可转化为支气管哮喘,因此也有人认为是哮喘的前驱阶段。从迄今为止的 CVA 报告来看,从3～4岁的幼儿到60岁以上的老人,各年龄组均可发生,但小儿病例几乎均在10岁以下。关于特异性因素方面,有此类既往史者为20～25%,有包括支气管哮喘在内的家族史者为40%～100%。CVA 的主要临床症状为不伴有喘鸣和呼吸困难的慢性咳嗽,虽多数为干性咳嗽,但湿性咳嗽时,咳痰几乎均为浆液或粘液性。咳嗽的持续时间各家报告 Recently, Japan has also started to use the concept of cough variant asthma (CVA) syndrome after Europe and the United States, and has drawn wide attention. The term CVA was first used in 1982 as a chronic cough without wheezing and breathing difficulties. Because of its hypersensitivity to airways and the fact that bronchodilators can make the cough go away, it is currently considered to be variant asthma. In addition, some cases can be transformed into bronchial asthma, it is also considered a precursor of asthma. According to CVA reports so far, children from 3 to 4 years of age to those over 60 years of age can occur in all age groups, but almost all pediatric cases are under 10 years of age. With regard to specificity, there are 20-25% of these past histories, with 40% to 100% of family history including bronchial asthma. The main clinical symptoms of CVA are chronic cough without wheeze and breathlessness, although most are dry coughs, whereas when wet coughs, sputum is almost serous or mucinous. The duration of cough reports for each