关于使用外源性孕激素对胎儿发育的影响各家意见不一。许多报导有不利影响,特别是女性生殖器男性化,尿道下裂,心血管畸形及VACTERL (包括骨骼、消化,呼吸及肾脏受累的多发畸形综合征)。也有认为接受孕激素对胎儿发育无影响。产生意见分歧的原因可能为使用的孕激素制剂不同,有的有雄激素活性,有的代谢成有不同激素活性的类固醇。由于近代使用17α-羟孕酮预防早产,黄体酮防止先兆子痫及习惯性流产不断增加,本文观察单用孕激素是否会增加胎儿先天性畸形的危险,对指导产科实践有密切关系。材料来自1936年1月1日至1974年12月31日在Mayo门诊部有产前检查的24,000份病历。产前仅使用各种孕激素而非其他激素或促性腺激素的儿童988例为用药组;另选小儿性别、母亲年龄及以前 Opinion on the impact of the use of exogenous progesterone on fetal development. Many reports have adverse effects, in particular masculinity of the female genitalia, hypospadias, cardiovascular malformations and VACTERL (multiple deformities syndromes involving bone, digestion, respiration and kidneys). There are also that accept progesterone has no effect on fetal development. The reasons for the disagreement may be that the progestin preparations used are different, some have androgen activity, and some have been metabolized into steroid with different hormone activity. As the use of 17α-hydroxyprogesterone prevent premature birth in modern times, progesterone prevent progesterone and habitual abortion increasing, this article to observe whether single pregnancy progesterone can increase the risk of congenital malformations of the fetus, which is closely related to the guidance of obstetric practice. MATERIALS From 24,000 medical records with prenatal examinations at the Mayo Clinic from January 1, 1936 to December 31, 1974. A total of 988 pre-natal children who used various progestins instead of other hormones or gonadotrophins were selected as the medication group. The other children’s gender, age and age