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患者女,21岁,双小腿暗红色斑块4个月,患甲状腺功能亢进症6个月。皮肤科情况:双小腿下半部前外侧见大片浸润性淡红色斑块,左侧:约12cm×20cm大小,右侧:约10cm×18cm大小,局部坚实肿胀,加压无凹陷,毛孔粗大呈橘皮样外观,局部毳毛旺盛粗黑,对称性分布。皮损组织病理示:表皮角化过度,毛囊角栓,表皮突变平,真皮明显增厚,胶原纤维广泛分离,少量炎症细胞浸润,阿新蓝染色阳性。诊断:Graves病并胫前黏液性水肿。
Female patient, 21 years old, double-shaded dark red plaque for 4 months, hyperthyroidism for 6 months. Dermatology: the lower half of the lower half of the anteroposterior see large infiltrative pink patches, left: about 12cm × 20cm size, right: about 10cm × 18cm size, local solid swelling, pressure without depression, large pores Orange peel-like appearance, partial bangs thick exuberant, symmetry distribution. Histopathological examination showed that epidermal hyperkeratosis, follicular keratin, epidermal mutation, thickening of dermis, extensive separation of collagen fibers, infiltration of a small amount of inflammatory cells and positive staining with alanine. Diagnosis: Graves disease and anterior tibial myxedema.