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目的:观察大补阴丸治疗女性特发性性早熟的临床效果。方法:70例女性特发性性早熟患者,随机分为观察组和对照组,各35例。对照组给予达菲林治疗;观察组在对照组治疗基础上给予大补阴丸治疗。治疗6月。观察子宫、卵巢大小、骨龄指数,检测雌二醇(E2)、卵泡生成激素(FSH)、黄体生成激素(LH)等。结果:总有效率观察组88.57%,对照组71.43%,2组比较,差异有统计学意义(P<0.05)。治疗后2组子宫、卵巢、骨龄指数均有明显改善,与本组治疗前比较,差异有统计学意义(P<0.05);观察组患者子宫、卵巢大小、骨龄指数显著低于对照组,与对照组比较,差异有统计学意义(P<0.05)。治疗后观察组FSH、LH、E2均有明显改善,与治疗前比较,差异有统计学意义(P<0.05),对照组FSH、LH有明显改善(P<0.05),E2无明显改善;观察组LH、FSH、E2均低于对照组,与对照组比较,差异有统计学意义(P<0.05)。结论:大补阴丸治疗女性特发性性早熟临床疗效明显,可改善第二性征发育,减小子宫、卵巢容积,减慢骨龄成熟速度。
Objective: To observe the clinical effect of Dabuyin Wan on female idiopathic precocious puberty. Methods: Seventy women with idiopathic precocious puberty were randomly divided into observation group and control group, with 35 cases in each group. The control group was given dafenlin treatment; the observation group was treated with Dabuyin Pill on the basis of the control group. June treatment. The uterus, ovary size, bone age index, estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were detected. Results: The total effective rate was 88.57% in the observation group and 71.43% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the uterus, ovaries and bone age index of two groups were significantly improved, with statistical significance (P <0.05) compared with those before treatment in the two groups; the uterus, ovary size and bone age index in the observation group were significantly lower than those in the control group The difference between the control group, the difference was statistically significant (P <0.05). After treatment, FSH, LH and E2 in the observation group were significantly improved, with statistical significance (P <0.05) before treatment, FSH and LH in the control group were significantly improved (P <0.05), E2 was not significantly improved; The levels of LH, FSH and E2 were lower in the control group than in the control group, with statistical significance (P <0.05). Conclusion: Dabuyin Pill is effective in treating idiopathic precocious puberty in female patients. It can improve the development of second sexual characteristics, reduce the volume of uterus and ovary, and slow down the maturation of bone age.