SHIV是在 SIV其因组框架的基础上利用基因重组技术以 HIV部分基因片段来取代 SIV相应基因而构建的一种重组病毒。SHIV与亲本株病毒有相似的生物学特性 ,能在 CD+ 4细胞、PBMCs、巨噬细胞中复制 ,并能引起猴发生 AIDS症状。另外 SHIV能诱使机体产生中和抗体 ,可以作为侯选疫苗株 ,在 AIDS预防中有广阔的前景。 SHIV is a recombinant virus constructed on the basis of the SIV frame by using the gene recombination technology to replace the corresponding gene of SIV with HIV partial gene fragments. SHIV has similar biological characteristics to the parental strain virus and can replicate in CD + 4 cells, PBMCs and macrophages and cause AIDS in the monkeys. In addition SHIV can induce the body to produce neutralizing antibodies, can be used as a candidate vaccine strain, in the prevention of AIDS have broad prospects.