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家族性高胆固醇血症(FH)是低密度脂蛋白(LDL)受体突变所致的一种严重疾病,常在早年死于心肌梗塞。近年来国内已有病例报道,初步推算,该病在我国的发病率并不低于欧美国家。因其病因特殊,一般降脂药物多难奏效,而具有一定疗效的回肠旁路、门-腔分流手术及肝脏移植等,因技术复杂尚难推广。FH的主要危害来自血液中过多的胆固醇,直
Familial hypercholesterolemia (FH) is a serious disease caused by mutation of low density lipoprotein (LDL) receptor, often died of myocardial infarction in early years. In recent years, there have been reports of cases in our country. According to preliminary estimates, the incidence of this disease in China is not lower than that in Europe and the United States. Because of its special etiology, generally lipid-lowering drugs more difficult to work, and have some effect of ileal bypass, door-cavity shunt surgery and liver transplantation, due to technical complexity is difficult to promote. The main hazard of FH comes from excess cholesterol in the blood, straight