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目的: 探讨老年期发病的帕金森病 (PD)患者运动障碍的特点。 方法:按 1∶1配对病例对照研究的方法,选取诊断明确的老年及普通年龄发病的帕金森病患者各 44例,用国际通用的帕金森病统一评分量表 (UPDRS)第Ⅲ部分进行运动评分,用条件logistic回归分析老年期发病的PD患者运动障碍的特点。 结果:老年组患者运动迟缓(10. 6±4. 2)分、轴性损害症状(10. 7±3. 8)分及运动功能总评分为 (28. 8±7. 9)分,与对照组比较 (相应的各项评分分别为: 7. 8±3. 5, 8. 1±4. 3, 22. 9±6. 6)明显增高 (P<0. 01)。老年组患者合并对运动功能有影响的全身疾病的比例(21例,占 47. 7% )较对照组(9例,占 20. 4% )明显增多 (P<0. 01),但即使排除这些全身疾病的影响,老年发病的PD患者运动迟缓、轴性损害症状及运动功能总评分仍较对照组高。 结论:在病程相同的情况下,老年发病的PD患者其运动损害较普通年龄发病者更为严重。
Objective: To investigate the characteristics of dyskinesia in senile patients with Parkinson’s disease (PD). Methods: According to the 1: 1 matched case-control study, 44 patients with diagnosed senile and common age-related Parkinson’s disease were enrolled in this study. The patients were divided into three groups according to the Part III of the Universal Parkinson’s Disease Rating Scale (UPDRS) Score, conditional logistic regression analysis of senile PD patients with dyskinesia characteristics. Results: The elderly patients had bradykinesia (10. 6 ± 4.2) points, axial damage symptoms (10. 7 ± 3. 8) points and total motor function score (28.8 ± 7.9), with Comparison of the control group (the corresponding scores were: 7. 8 ± 3.5, 8. 1 ± 4.3, 22. 9 ± 6. 6) was significantly higher (P <0.01). Older age patients with motor function affect systemic disease (21 cases, 47.7%) than the control group (9 cases, 20.4%) was significantly increased (P <0.01), but even excluding The impact of these systemic diseases, geriatric PD patients with exercise retardation, axial damage symptoms and motor function score was still higher than the control group. Conclusion: In the same course of disease, the incidence of motor impairment in elderly patients with PD is more serious than that of normal age.