A new method for preparation of the potent hypoglycemic KAD-1229 was developed.The key step of this method is diasteroselective alkylation in high optical purit
2-Alkylamino-5, 6, 7, 8-tetrahydrobenzothieno [2, 3-d] pyrimidin-4(3H)-ones 7 were synthesized by a new selective synthetic method, which includes aza-Wittig re