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本文报道了鄱阳湖区人群化疗后血吸虫再感染的纵向观察结果．分析了人群再感染易感性与血吸虫特异性抗体同型的关系。结果显示，人群再感染率与当地疫情相平行，表明暴露是影响再感染的主要因素；平衡暴露因素后，低年龄组重度再感染高于高年龄组，相对危险废为1．6－2．5；非条件Logistic分析表明，低年龄组较高年龄组容易发生再感染，且“拮抗组”较“易感组”平均年龄大11－13岁，证明日本血吸虫感染者中可产生年龄依赖性获得性免疫；AWA特异性IgE为再感染的“拮抗”因素，SEA／AAA特异性IgG为易感因素．本项研究探讨了人体在自然感染状态下抗血吸虫再感染抗力的发展规律，为日本血吸虫疫苗的研制和疫苗的现场应用提供了流行病学的依据．
This paper reports the longitudinal observation of schistosoma infection in Poyang Lake area after chemotherapy. The relationship between susceptibility to human re-infection and isotypes of schistosome-specific antibodies was analyzed. The results showed that the re-infection rate was parallel with the local epidemic, indicating that exposure was the main factor affecting reinfection. After exposure, the severe re-infection in the lower age group was higher than that in the older age group, and the relative risk was 1.6-2. 5; unconditional Logistic analysis showed that re-infection was more likely in the lower age group than in the older age group, and that in the “antagonistic group” was 11-13 years older than the “susceptible group”, proving that the age-dependent Acquired immunity; AWA-specific IgE is re-infected “antagonist” factor, SEA / AAA-specific IgG as susceptibility factors. This study explored the development of human anti-schistosoma re-infection resistance under natural infection and provided an epidemiological basis for the development of vaccine against Schistosoma japonicum.