自身免疫性疾病(autoimmune disease，AID)是遗传易感个体的多因素疾病，调节性B细胞(regulatory B cell，Bregs)通过产生白细胞介素(interleukin，IL)-10、IL-35、转化生长因子-β(tumor necrosis factor-β，TGF-β)在AID中发挥重要作用。多发性硬化(multiple sclerosis，MS)是一类重要的神经系统免疫性疾病，在MS实验性自身免疫性脑脊髓炎模型(experimental autoimmune encephalomyelitis，EAE)中，缺乏Bregs会导致更严重和更急性的EAE，这表明Bregs在抑制早期阶段疾病的启动和发展中尤为重要。文章就Bregs通过分泌细胞因子IL-10、IL-35、TGF-β抑制MS炎症反应的机制进行综述。“,”Autoimmune disease(AID) is a multifactorial disease of genetically susceptible individuals.Regulatory B cell(bregs) plays an important role in autoimmune diseases by producing interleukin(IL)-10, IL-35 and tumor necrosis factor-β(TGF-β). Multiple sclerosis(MS) is an important nervous system immune disease.In the experimental autoimmune encephalomyelitis(EAE) model of MS, the lack of Bregs can lead to the development of more severe and acute EAE, which indicates that Bregs is particularly important in inhibiting the initiation and development of early stage diseases.This review summarized the mechanism of Bregs inhibiting the inflammatory response of MS by secreting cytokines IL-10, IL-35 and TGF -β.