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为研究小儿重症肌无力(MG)血清乙酰胆碱受体抗体(AchRab)的含量改变及其临床意义。采用固相酶联免疫吸附法检测血清AchRab的含量。结果MG患儿血清AchRab阳性率为81%,明显高于健康对照组和非MG病人组(P<0.01)。MG患儿治疗后血清AchRab的含量明显低于治疗前,其阳性率分别为55%和81%(P<0.05)。结果提示AchRab的测定可作为MG患儿早期诊断和疗效观察的指标。
In order to study the changes of serum AchRab in children with myasthenia gravis (MG) and its clinical significance. Serum AchRab levels were determined by solid-phase enzyme-linked immunosorbent assay. Results The positive rate of serum AchRab in children with MG was 81%, which was significantly higher than that of healthy controls and non-MG patients (P <0.01). The serum AchRab levels in children with MG were significantly lower than those before treatment, and the positive rates were 55% and 81%, respectively (P <0.05). The results suggest that the determination of AchRab can be used as an indicator of early diagnosis and treatment of MG in children.