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[目的]探讨p27在宫颈癌中的表达及其临床意义。[方法]应用免疫组化法检测50例宫颈癌、25例宫颈上皮内瘤样变(CIN)和10例正常宫颈组织石蜡包埋组织中p27蛋白的表达。[结果]p27在宫颈癌中的阳性表达率为32.00%(16/50),在CIN中的阳性表达率为56.00%(14/25),在正常宫颈组织中的阳性表达率为80.00%(8/10),三者比较差异有统计学意义(P<0.01)。p27高表达与宫颈癌患者的年龄、临床分期、病理类型、组织学分级均无相关性(P>0.05)。[结论]p27在宫颈癌低表达,其可作为宫颈癌癌前病变的生物学标志物。
[Objective] To investigate the expression of p27 in cervical cancer and its clinical significance. [Method] Immunohistochemistry was used to detect the expression of p27 protein in 50 cases of cervical cancer, 25 cases of cervical intraepithelial neoplasia (CIN) and 10 cases of normal cervical tissue paraffin-embedded tissues. [Results] The positive expression rate of p27 in cervical cancer was 32.00% (16/50), the positive expression rate in CIN was 56.00% (14/25), and the positive expression rate in normal cervical tissue was 80.00% ( 8/10), the difference between the three was statistically significant (P <0.01). There was no correlation between p27 overexpression and age, clinical stage, pathological type and histological grade of cervical cancer (P> 0.05). [Conclusion] The low expression of p27 in cervical cancer can be used as a biological marker of cervical precancerous lesions.