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自1975年发现脑啡肽至今已有10年,在此期间已发现一系列的内源性阿片肽类;但迄今这些肽的生理意义还未阐明。最近Hansjorg Teschemacher 等根据一系列实验资料提出:阿片肽可能具有免疫学意义。首先,阿片肽可以和免疫系统的细胞成分或体液成分,如淋巴细胞、粒细胞、肥大细胞和补体系统相互作用,调节抗体的生成、T 细胞玫瑰花结试验以及T 细胞的增殖等过程。这些作用有的是通过阿片受体实现的(可被纳洛酮阻断),有的则是通过非阿片受体实现的。
It has been 10 years since the enkephalin was discovered in 1975, during which time a series of endogenous opioid peptides have been found; but the physiological significance of these peptides so far has not been elucidated. According to a series of experimental data, Hansjorg Teschemacher and others recently proposed that opioid peptide may be of immunological significance. First, opioids interact with cellular or humoral components of the immune system, such as lymphocytes, granulocytes, mast cells and the complement system, modulating antibody production, the T cell rosetting assay, and the proliferation of T cells. Some of these effects are achieved by opioid receptors (which can be blocked by naloxone), while others are mediated by non-opioid receptors.