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药代动力学参数在种属之间存在差异性,但同时亦看到种属之间在解剖学和生理学上有许多相似性,这种相似性构成了生物医学的研究基础。Adolph观察到在解剖学和生理学特征上许多变量,按不同动物体重的指数建立相关性。其表达式为:特征=(体重)指数,称之异速增大模型(Allometric Model),于是,特征参数值通过动物体重,按照所谓比例扩大(Scaling up)方式预报出人类的特征性参数值,已取得一定成效。
Pharmacokinetic parameters vary among species, but there are also many similarities in anatomy and physiology seen between species, which form the basis of biomedical research. Adolph observed many variables in anatomical and physiologic characteristics, establishing associations by body weight index for different animals. The expression is: The characteristic = (body weight) index, known as the Allometric Model, then the characteristic parameter value predicts the characteristic parameter value of human through the body weight of an animal according to the so-called scaling method , Has achieved some success.