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通过测定大鼠心脏易损期内不同时刻的室颤阈,估价室颤阈反映心室易颤性的可靠程度。在易损期内不同时刻测得的室颤阈相差13.1±6.4mA。在加快心率、心得安和左冠脉结扎等因素的影响下,在易损期内不同时刻,室颤阈变化的程度相差很大。因此,用易损期中某一时刻的室颤阈反映心室易颤性是不太可靠的。用室颤阈的变化幅度反映某因素对心脏易颤性的影响程度也是不太精确的。本实验提示易损期时程可较好地反映心脏易颤性。
The ventricular fibrillation threshold was assessed to reflect the reliability of ventricular fibrillation by measuring the ventricular fibrillation threshold at different times in the heart vulnerable part of the rat heart. The ventricular fibrillation thresholds measured at different times during the vulnerable period differed by 13.1 ± 6.4 mA. Under the influence of accelerating heart rate, propofol and left coronary artery ligation, the thresholds of ventricular fibrillation varied greatly at different times during the period of vulnerability. Therefore, it is less reliable to report ventricular fibrillation with a ventricular fibrillation threshold at some point in the vulnerable phase. Using the magnitude of the change in ventricular fibrillation threshold to reflect the extent to which a factor affects the heart’s vulnerability is less precise. This experiment suggests that the duration of vulnerable period can better reflect the heart vulnerable heart.