Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic mod

来源 :Asian Pacific Journal of Tropical Medicine | 被引量 : 0次 | 上传用户:yaqi007666
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Objective:To evaluate the antidiabetic and antioxidant potential of Emblica officinalis(E.officinalis)fruit on normal and type 2 diabetic rats.Methods:Type 2 diabetes was induced into the male Long-Evans rats.The rats were divided into nine groups including control groups receiving water,type 2 diabetic controls,type 2 diabetic rats treated with glibenclamide(T2GT)and type 2diabetic rats treated with aqueous extract of fruit pulp of E.officinalis.They were fed orally for8 weeks with a single feeding.Blood was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 day.Packed red blood cells and serum were used for evaluating different biochemical parameters.Results:Four weeks administration of aqueous extract of E.officinalis improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant(P<0.007)reduction in fasting serum glucose level compared to 0 day.Triglycerides decreased by 14%but there was no significant change in serum ALT,creatinine,cholesterol and insulin level in any group.Furthermore,reduced erythrocyte malondialdehyde level showed no significant change(P<0.07)but reduced glutathione content was found to be increased significantly(P<0.05).Conclusions:The aqueous extract of E.officinalis has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development. Objective: To evaluate the antidiabetic and antioxidant potential of Emblica officinalis (E. officinalis) fruit on normal and type 2 diabetic rats. Methods: Type 2 diabetes was induced into the male Long-Evans rats. The rats were divided into nine groups including control groups receiving water, type 2 diabetic controls, type 2 diabetic rats treated with glibenclamide (T2GT) and type 2diabetic rats treated with aqueous extract of fruit pulp of E.officinalis. they were fed orally for 8 weeks with a single feeding .lood was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 day. Packed red blood cells and serum were used for evaluating different biochemical parameters. Results: Four weeks administration of aqueous extract of E. officinalis improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant (P <0.007) reduction in fasting serum glucose level compared to 0 day.Triglycerides decreased by 14% but there was no significant change in serum ALT, creatinine , cholesterol and insulin level in any group. Frthermore, reduced erythrocyte malondialdehyde level showed no significant change (P <0.07) but reduced glutathione content was found to be increased significantly (P <0.05) .Conclusions: The aqueous extract of E.officinalis has a promising antidiabetic and antioxidant properties and may be considered further further studies in drug development.
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