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将口服降血糖药物血糖控制不佳的老年T2DM患者随机分为给予诺和锐30注射液,取全日胰岛素总量50%分别于早、晚餐前10min内腹壁皮下注射;对照组给予诺和灵30R,取全日胰岛素总量的2/3和1/3分别于早、晚餐前15~30min腹壁皮下注射,观察降糖疗效。结果治疗组空腹血糖和早餐后两小时血糖水平明显低于对照组(P均<0.01),低血糖发生率低于对照组(P<0.01);两组HbA1c水平、胰岛素用量及其他不良事件发生率差异无显著性。结论诺和锐30控制老年T2DM餐后血糖较诺和灵30R更为满意,低血糖发生率减少。
The elderly patients with T2DM with poor glycemic control of oral hypoglycemic drugs were randomly assigned to receive Noro Rui 30 injection, 50% of the total daily insulin amount was injected subcutaneously into the abdominal wall within 10 minutes before breakfast and dinner, respectively. The control group received Novolin 30R , Taking 2/3 and 1/3 of the total daily insulin in the abdominal wall of 15-30 minutes before breakfast and dinner respectively to observe the effect of hypoglycemic. Results The fasting blood glucose in the treatment group and the two hours after breakfast were significantly lower than those in the control group (P <0.01), and the incidence of hypoglycemia was lower in the treatment group than in the control group (P <0.01). HbA1c levels, insulin dosage and other adverse events Rate difference was not significant. Conclusions Nuo-Rui-Rui 30 controlled postprandial blood glucose of T2DM patients is more satisfied than Noro-Ling 30R, the incidence of hypoglycemia is reduced.