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碳-磷键的形成反应在有机磷合成中占有重要地位,烷基磷酸二烷基酯是一类具有实用价值的有机磷化合物,因此其合成方法受到人们重视。Michaelis-Becker反应是合成这类化合物的重要方法之一,但由于反应条件剧烈,常有副反应产生,其一是亚磷酸二烷基酯与其钠盐易发生岐化反应,另一是反应中所形成的卤化盐促进产物烷基膦酸酯与烷基卤的酯交换反应,从而影响了产物纯度与产率,烷基氯或具空间位阻的烷基溴与亚磷酸二烷基酯钠的反
The formation reaction of carbon-phosphorus bonds plays an important role in the synthesis of organic phosphorus. Dialkyl phosphate is a kind of organic phosphorus compounds with practical value. Therefore, its synthesis method has drawn great attention. Michaelis-Becker reaction is one of the important methods for the synthesis of these compounds. However, due to the violent reaction conditions, side reactions often occur. One is that the dialkyl phosphite is easily disproportionated with its sodium salt and the other is the reaction The formed halogenated salt facilitates the transesterification of the product alkyl phosphonate with the alkyl halide thereby affecting the product purity and yield, the reaction of the alkyl chloride or the sterically hindered alkyl bromide with sodium dialkyl phosphite The anti