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目的探讨神经生长因子(NGF)在涎腺腺样囊性癌(ACC)不同病理组织学类型中的表达及其与嗜神经性的关系和临床意义。方法采用免疫组织化学S-P法,检测NGF在43例涎腺腺样囊性癌组织中的表达,并分析它与涎腺腺样囊性癌病理组织学类型和嗜神经性的关系及其与生存率的关系。结果NGF在ACC不同病理组织学类型中的表达差异有统计学意义(P<0.05);NGF在嗜神经现象组与无嗜神经现象组间的阳性表达差异也有统计学意义(P<0.05)。结论NGF在ACC中的表达强度与ACC病理组织学类型及嗜神经性有一定相关性,可作为该肿瘤预后判断的指标。
Objective To investigate the expression and clinical significance of nerve growth factor (NGF) in different histopathological types of salivary adenoid cystic carcinoma (ACC). Methods Immunohistochemical SP method was used to detect the expression of NGF in 43 cases of salivary adenoid cystic carcinoma and its relationship with the survival of the salivary adenoid cystic carcinoma Rate of relationship. Results The expression of NGF in different histopathological types of ACC was significantly different (P <0.05). There was also a significant difference in the expression of NGF between the neuropathic group and non-neuropathic group (P <0.05). Conclusion The expression of NGF in ACC has some correlation with histopathological types and neuropathic features of ACC, which can be used as an indicator of the prognosis of the tumor.