各种肾脏疾病有不同特征和形式的细胞增生,其间有诸多因素如多种生长因子及其相应的受体、增殖信号传递蛋白、转录和翻译因子等参与,近年研究表明各种生理病理因素最终的共同途径将作用于细胞周期,通过对参与细胞周期特异性调节蛋白的影响决定其结局(肥大、凋亡、增殖或分化) [ Various kidney diseases have different characteristics and forms of cell proliferation, during which there are many factors such as a variety of growth factors and their receptors, proliferative signaling proteins, transcription and translation factors involved in recent years, studies have shown that various physiological and pathological factors eventually Will act on the cell cycle and determine its outcome (hypertrophy, apoptosis, proliferation or differentiation) through its involvement in the regulation of cell cycle-specific proteins [