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目的观察初诊2型糖尿病患者经诺和锐30特充强化治疗后胰岛β细胞功能的变化。方法对55例初诊为2型糖尿病的患者进行为期2周的诺和锐30特充治疗,每日3次皮下注射,分析治疗前后口服葡萄糖耐量试验(OGTT)时空腹血糖(FPG)、糖负荷后血糖(PPG)、胰岛素、C-肽、胰岛素及C-肽曲线下面积、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-B)等指标的变化。结果短期诺和锐30特充强化治疗后,FPG、PPG较治疗前明显下降(P<0.01),胰岛素、C-肽、胰岛素及C-肽曲线下面积、HOMA-B较治疗前明显升高(P<0.01),HO-MA-IR较治疗前明显下降(P<0.05)。总胆固醇、甘油三脂治疗前后差异无统计学意义(P>0.05)。结论短期诺和锐30特充强化治疗可迅速降低血糖,改善胰岛β细胞功能,减轻胰岛素抵抗。
Objective To observe the changes of islet β-cell function in patients with newly diagnosed type 2 diabetes mellitus (T2D) after intensive and intensive treatment with Novo-Rui-30. Methods Fifty-five patients with newly diagnosed type 2 diabetes were treated with Novo Ruirui 30 for 2 weeks and were injected subcutaneously three times a day. The levels of fasting blood glucose (FPG) and glucose load (OGTT) before and after oral glucose tolerance test (OGTT) Blood glucose (PPG), insulin, C-peptide, insulin and C-peptide area under the curve, insulin resistance index (HOMA-IR), insulin secretion index (HOMA-B) and other indicators of change. Results Compared with pretreatment, FPG and PPG significantly decreased (P <0.01), and the area under the curve of insulin, C-peptide, insulin and C-peptide, HOMA-B was significantly higher than that before treatment (P <0.01), HO-MA-IR significantly decreased compared with that before treatment (P <0.05). There was no significant difference in total cholesterol and triglyceride before and after treatment (P> 0.05). CONCLUSION Short-term Nuo-Rui-Rui 30 Extra-intensive Intensive Treatment can rapidly lower blood glucose, improve pancreatic β-cell function and reduce insulin resistance.