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目的 建立母婴人类巨细胞病毒感染相关性数学模型。方法 以ELISA及PCR技术对母婴血浆HCMV -IgM及血浆和P(C)BMCsHCMV -DNA进行了检测。结果 母婴HCMV感染之间存在明显的相关性 ,而且母亲血浆中HCMVDNA与HCMV先天性感染相关性最大 ,其Spearman等级相关系数达 0 70 18(P <0 0 0 0 1)。另外也作了从母亲HCMV检测结果判断HCMV先天性感染的Fisher二类判别分析 ,并建立了Fisher二类判别函数。经回代判别 ,本判别函数用于判断HCMV先天性感染的准确性达 91 2 %。结论 母婴HCMV感染之间存在明显的相关性 ,并且可以通过检测母亲HCMV来推测其胎儿HCMV先天感染的可能性。
Objective To establish a mathematical model of human cytomegalovirus infection in maternal and infant patients. Methods Plasma HCMV-IgM, plasma and P(C)BMCsHCMV-DNA were detected by ELISA and PCR. Results There was a significant correlation between mother-to-child HCMV infection, and maternal plasma HCMV DNA had the greatest correlation with HCMV congenital infection, with a Spearman rank correlation coefficient of 0 70 18 (P < 0.0001). In addition, Fisher’s second-class discriminant analysis to determine HCMV congenital infection from the results of maternal HCMV test was also made, and a Fisher second-class discriminant function was established. After retrogression, the discriminant function used to determine the accuracy of HCMV congenital infection reached 91 2%. Conclusion There is a significant correlation between maternal and child HCMV infections, and the possibility of fetal HCMV congenital infection can be estimated by detecting maternal HCMV.