动物实验和初步临床研究提示，早期行clodrnate治疗能降低乳腺癌新发骨转移的发生率。为了解clodrnate对乳腺癌转移情况的历响，德国海德堡大学医院妇产科InsoJDiel等，进行了一项前瞻性随机非安慰剂对照研究。作者将1990年至1995年302例骨拥中发现癌细胞（远处转移的危险因素 Animal experiments and preliminary clinical studies suggest that early treatment with clodrnate can reduce the incidence of new bone metastases in breast cancer. To understand the history of clodnate’s metastasis of breast cancer, a prospective, randomized, non-placebo-controlled study was conducted by InsoJDiel et al., Department of Gynecology and Obstetrics, University Hospital Heidelberg, Germany. The authors detected cancer cells in distant metastases in 302 cases from 1990 to 1995