月经过多是育龄女性的一种常见病症,多见于子宫肌瘤等宫腔病变者,但仍约有半数月经过多女性,无明显妇科病因,月经过多原因未明〔1〕。近年有文献报道,在此类“病因”未明的月经过多女性中,有相当比例者止凝血功能低下,其中以血管性血友病(von Willebrand disease,vWD)尤为高发,检出率达13%〔2〕,发病主要因血液中血管性血友病因子(von Willebrand factor,vWF)出现量或功能异常,致止凝血功能低下,各种出血事件发生。vWD女性日常出 Menorrhagia is a common disease of women of childbearing age, more common in uterine fibroids and other uterine lesions, but still about half of menorrhagia women, no obvious causes of gynecology, menorrhagia and unexplained [1]. In recent years, it has been reported in the literature that a significant proportion of women with excessive menorrhagia whose “etiology” is unknown have only low coagulation function, of which von Willebrand disease (vWD) is particularly prevalent Up to 13% 〔2〕, the incidence mainly due to blood von Willebrand factor (vWF) in the amount or dysfunction, causing clotting dysfunction, a variety of bleeding events. vWD women out daily