蛋白酶抑制剂(protease inhibitor,PI)作为一类主要的抗逆转录病毒药物,与其它的抗逆转录病毒药物一起,组成高效抗逆转录病毒疗法(high active antiretroviral therapy,HAART)。这种疗法明显的降低了艾滋病的病死率,使其从一种致死性疾病成为一种慢性疾病,但与此同时,它也带来了一些明显的副作用,如增加糖尿病和心血管疾病的发生率。关于这类药物诱导糖尿病的机制。国内未见报道。本文就此作一综述。 As a major antiretroviral drug, protease inhibitors (PIs), together with other antiretroviral drugs, constitute a high active antiretroviral therapy (HAART). This treatment significantly reduces AIDS mortality from a lethal disease into a chronic disease, but in the meantime, it also brings some obvious side effects, such as increased incidence of diabetes and cardiovascular disease rate. About the mechanism of these drugs to induce diabetes. No domestic reports. This article gives a summary of this.