【摘 要】
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As a kind of environmentally benign reagents,α-keto acids have been extensively employed as key starting materials in organic synthesis.Organic electrosynthesis has the advantages of reducing byproduct generation,improving the cost-efficiency of synthetic
【机 构】
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Green Catalysis Center,College of Chemistry,Zhengzhou University,Zhengzhou 450001,China;Faculty of E
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As a kind of environmentally benign reagents,α-keto acids have been extensively employed as key starting materials in organic synthesis.Organic electrosynthesis has the advantages of reducing byproduct generation,improving the cost-efficiency of synthetic processes,and accessing reactive intermediates under mild conditions.Inspired by the merits of organic electrosynthesis,α-keto acids have shown many synthetic applications in electrochemical acylation,cyclization,and reductive amination reactions with improved efficiencies and selectivities.This review covers the recent breakthroughs achieved in the electrochemical transformations of α-keto acids,aimed at highlighting these electrochemical reactions\' features and mechanistic rationalisations.Meanwhile,the practicalities and limitations of these transformations are also presented where possible.
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