目的 :探讨米索前列醇阴道给药用于足月妊娠引产的临床合理剂量。方法 :2 10例有用药指征的孕妇随机分为 3组 ,均采用米索前列醇阴道给药。 2 5μg组 :2 5μg ,q 4h ;50 μg组 :50 μg ,q 18h ;10 0 μg组 :10 0 μg ,q 2 4h。结果 :10 0 μg组和 50 μg组引产时间显著少于 2 5μg组 (均P <0 .0 5) ,3组宫缩过频的发生率依次为 2 1% ,4 % ,10 % ,(P <0 .0 1)。 3组脐动脉血流速度测定及剖宫产率差别无显著意义 (均P >0 .0 5)。结论 :米索前列醇 50 μg阴道给药 q 18h有较好的引产效果 ,且宫缩过频的发生率相对减少。米索前列醇用于足月妊娠引产在4 8h内不超过 2 0 0 μg对母婴是安全的 Objective: To investigate the clinical reasonable dose of misoprostol for vaginal delivery of term pregnancy. Methods: A total of 210 pregnant women with indications of drug use were randomly divided into 3 groups, all of whom were vaginally administered with misoprostol. 2 5μg group: 25μg, q 4h; 50μg group: 50μg, q 18h; 100μg group: 100μg, q 2 4h. Results: The time of induction of labor was significantly less in the 10 μg and 50 μg groups than in the 25 μg group (all P <0.05). The incidences of uterine contractions in the 3 groups were 21%, 4% and 10%, respectively P <0 .0 1). There was no significant difference between the three groups in the determination of umbilical artery blood flow velocity and cesarean section rate (all P> 0.05). Conclusion: Misoprostol 50 μg vaginal administration of q 18h has a good induction of labor, and the incidence of uterine contractions is relatively reduced. Misoprostol for term pregnancy induction of labor does not exceed 200 μg within 48 h is safe for mother and baby