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目的:探讨Kaposi’s肉瘤中转化生长因子Ⅱ型受体基因(TGF-βRⅡ)的表达特点及其意义。方法:采用免疫组织化学技术检测30例Kaposi’s肉瘤组织和30例皮肤良性血管瘤组织中TGF-βRⅡ的表达。结果:TGF-βRⅡ基因在Kaposi’s肉瘤真皮瘤体中的表达阳性率为46.7%(14/30),在血管瘤真皮瘤体中表达阳性率为66.7%(20/30),(P<0.05)。TGF-βRⅡ基因在Kaposi’s肉瘤表皮中表达的阳性率为63.3%(19/30),在血管瘤表皮中为53.3%(16/30),差异没有统计学意义(P>0.05)。结论:TGF-βRⅡ基因在真皮瘤体中的表达与Kaposi’s肉瘤的发生相关。
Objective: To investigate the expression and significance of transforming growth factor type Ⅱ receptor gene (TGF-βRⅡ) in Kaposi’s sarcoma. Methods: The expression of TGF-βRⅡ in 30 cases of Kaposi’s sarcoma and 30 cases of benign hemangiomas was examined by immunohistochemistry. Results: The positive rate of TGF-βRⅡ gene in Kaposi’s sarcoma dermis was 46.7% (14/30), the positive rate of TGF-βRⅡ was 66.7% (20/30) (P <0.05) . The positive rate of TGF-βRⅡgene in the epidermis of Kaposi’s sarcoma was 63.3% (19/30), and it was 53.3% (16/30) in the hemangioma epidermis. The difference was not statistically significant (P> 0.05). Conclusion: The expression of TGF-βRⅡ in dermal tumors is related to the development of Kaposi’s sarcoma.