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本文用高压液相色谱法检测CSF(脑脊液)中吡喹酮含量,测得脑囊虫病患者CSF中吡喹酮浓度为血浓度的17-22.5％,与正常人相似。慢性脑膜炎患者CSF中吡喹酮浓度仅为血浓度的4.6％,其血脑屏障透过率明显低于囊虫病患者。本文各治疗组CSF中吡喹酮浓度均可达体外杀灭血吸虫和囊虫的最低有效浓度。
In this paper, praziquantel concentration in CSF (cerebrospinal fluid) was measured by high pressure liquid chromatography. The concentration of praziquantel in CSF of patients with cysticercosis was 17-22.5% of the blood concentration, which was similar to that in normal people. The concentration of praziquantel in CSF of chronic meningitis is only 4.6% of the blood concentration, and its blood-brain barrier permeability is obviously lower than that of cysticercosis patients. In this paper, the concentration of praziquantel in the CSF of each treatment group can reach the minimum effective concentration for killing schistosome and cysticercosis in vitro.