目的探讨慢性心力衰竭(CHF)患者血浆脂联素(APN)和氧化低密度脂蛋白(oxLDL)与心功能的关系。方法选择124例CHF患者,按NYHA心功能分级分为3组(心功能Ⅱ级,Ⅲ级,Ⅳ级组),40例健康体检者为对照组,应用酶联免疫法测定2组血浆APN和oxLDL水平,进行组间统计学比较及各参数之间的相关分析。结果 CHF患者基础血浆APN和oxLDL水平明显高于健康对照组(P<0.01),且随NYHA级别的增加而增高(P<0.01);CHF患者的血浆APN和oxLDL水平经治疗后较治疗前均明显下降(P<0.01);缺血型心肌病心衰和扩张型心肌病心衰两组之间血浆APN和oxLDL水平差异无统计学意义(P<0.01);血浆APN与oxLD两者呈正相关(r=0.627,P<0.01)。结论 CHF患者血浆APN和oxLDL显著增高,并与CHF严重程度存在正相关性;缺血性心肌病心衰与扩张型心肌病心衰两组之间血浆APN与oxLD均升高,且无相关性。 Objective To investigate the relationship between plasma adiponectin (APN) and oxidized low density lipoprotein (oxLDL) and cardiac function in patients with chronic heart failure (CHF). Methods A total of 124 patients with CHF were divided into three groups (NYHA class Ⅱ, Ⅲ and Ⅳ) according to NYHA functional classification. Forty healthy controls were used as control group. The levels of plasma APN, oxLDL levels, statistical comparison between groups and the correlation between the various parameters. Results The levels of plasma APN and oxLDL in CHF patients were significantly higher than those in healthy controls (P <0.01), and increased with NYHA level (P <0.01). Plasma APN and oxLDL levels in CHF patients were significantly lower than those before treatment (P <0.01). There was no significant difference in plasma APN and oxLDL levels between the two groups (P <0.01), but there was a positive correlation between plasma APN and oxLD in the patients with heart failure of ischemic cardiomyopathy and heart failure with dilated cardiomyopathy (r = 0.627, P <0.01). Conclusions Plasma APN and oxLDL were significantly increased in patients with CHF, and positively correlated with the severity of CHF. Plasma APN and oxLD levels in both CHF group and CHF group were significantly higher than those in non-ischemic cardiomyopathy .