缩氨基硫脲衍生物及其金属配合物具有抗肿瘤、抗病毒、抗真菌及抗细菌活性。但这类化合物却很少应用于临床,原因之一是其水溶性很小。因此,我们设计在这类化合物中引入了一个或多个亲水性基团。本研究合成了9种糖类缩氨基硫脲衍生物及它们的5种过渡金属配合物。其中,1种糖衍生物及其 Thiosemicarbazone derivatives and their metal complexes have anti-tumor, anti-virus, anti-fungal and antibacterial activities. However, these compounds are rarely used clinically, one of the reasons is that their water solubility is small. Therefore, we designed to introduce one or more hydrophilic groups into these compounds. In this study, nine kinds of carbohydrate thiosemicarbazone derivatives and their five kinds of transition metal complexes were synthesized. Among them, one kind of sugar derivatives and their