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目的探讨血清肝细胞生长因子(hepatocyte growth factor,HGF)与胃癌的发生、发展及转移的关系。方法应用双抗体夹心ELISA方法检测、比较40例初发胃癌患者(其中已转移的有14例,无转移的26例;其中36例行胃癌切除术),15例胃癌复发患者与20例献血员(正常对照组)的血清肝细胞生长因子水平。结果胃癌复发患者高于胃癌初发者(P<0.01),胃癌术前患者显著高于正常对照组和胃癌术后患者(P<0.01),胃癌已转移的患者显著高于无转移的患者(P<0.01)。结论血清肝细胞生长因子水平与胃癌发生、发展及转移密切相关。
Objective To investigate the relationship between serum hepatocyte growth factor (HGF) and the occurrence, development and metastasis of gastric cancer. Methods Double antibody sandwich ELISA was used to detect 40 cases of primary gastric cancer (14 cases had metastasis, 26 cases without metastasis; 36 cases had gastric cancer resection), 15 cases of gastric cancer recurrence and 20 cases of blood donors (Normal control group) serum hepatocyte growth factor levels. Results The recurrence rate of gastric cancer patients was higher than that of primary cancer patients (P <0.01). The number of preoperative gastric cancer patients was significantly higher than that of normal control group and postoperative gastric cancer patients (P <0.01). The metastasis rate of gastric cancer patients was significantly higher than that of non-metastatic patients P <0.01). Conclusion The level of serum hepatocyte growth factor is closely related to the occurrence, development and metastasis of gastric cancer.