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目的考察四乙酰葛根素(4ac)在大鼠小肠中的吸收情况。方法采用大鼠在体小肠单向灌流模型,通过HPLC法测定出口处灌注液中4ac的浓度,计算4ac在小肠各个肠段的吸收速率常数(Ka)及药物表观吸收系数(Papp)。结果 4ac在小肠段的吸收情况是十二指肠>回肠>空肠,4ac浓度为100μg·mL-1与150μg·mL-1在十二指肠的吸收情况无显著性差异(P>0.05)。结论 4ac主要在十二指肠段吸收,可开发为口服制剂。
Objective To investigate the absorption of tetraacetyl puerarin (4ac) in rat small intestine. Methods The rat model of intestinal small intestine was established. The concentration of 4ac in the perfusate was measured by HPLC. The absorption rate constant (Ka) and apparent drug absorption coefficient (Papp) of 4ac in each intestine were calculated. Results The absorption of 4ac in the small intestine was duodenum> ileum> jejunum. There was no significant difference in the absorption of 4ac between 100μg · mL-1 and 150μg · mL-1 in the duodenum (P> 0.05). Conclusions 4ac is mainly absorbed in the duodenum and can be developed as an oral preparation.