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染色体易位作为人类肿瘤细胞中的主要改变已被人们所知。在恶性细胞内,常有许多种染色体异常发生(包括染色体数目和形态结构异常),易位似乎是人类肿瘤细胞的标记。慢性粒细胞性白血病(CML) CML与异常短的22号染色体(Ph~1染色体)有规律性的相关,自1973年以来,人们就已知短的22号染色体不是缺失,而是通常有一部分与9号染色体发生易位。 Burkitt淋巴瘤 1973年就有报告指出,Burkitt淋巴瘤细胞中有14号染色体伸长。几年后,人们就识别出14号染色体伸长不是染色体重复,而是一部分8号染色体易位。因此,Burkitt淋巴瘤与慢性粒细胞性白
Chromosome translocation has been known as a major change in human tumor cells. In malignant cells, there are often many kinds of chromosomal abnormalities (including chromosome number and morphological abnormalities). Translocation seems to be a marker of human tumor cells. Chronic myelogenous leukemia (CML) CML is regularly associated with an unusually short chromosome 22 (Ph~1 chromosome). Since 1973, it has been known that short chromosome 22 is not missing, but is usually part of Translocation with chromosome 9 occurs. Burkitt’s lymphoma has been reported in 1973 to indicate chromosome 14 elongation in Burkitt’s lymphoma cells. A few years later, people recognized that chromosome 14 elongation is not a chromosomal repeat, but part of chromosome 8 translocation. Therefore, Burkitt’s lymphoma and chronic granulocyte white