目的观察乳果糖治疗老年人便秘的疗效和安全性。方法本院住院老年慢性便秘患者65例,随机分为乳果糖治疗组和饮食调节组。乳果糖组在观察1周导入期后,每日早餐时服用乳果糖15毫升,共治疗3周。每周随访1次,记录大便次数,性状,不良反应和评定疗效。结果乳果糖治疗组的患者在服药开始后3天内,便秘症状迅速减轻。到治疗第3周时,乳果糖治疗组有91%患者感疗效满意;而饮食调节组有35.5%患者认为疗效满意。两组的疗效差异有统计显著性。两组均无重要不良反应。结论乳果糖是治疗老年人慢性便秘的有效、安全的药物,适合在基层医院广泛应用。 Objective To observe the efficacy and safety of lactulose in the treatment of constipation in the elderly. Methods 65 hospitalized elderly patients with chronic constipation were randomly divided into lactulose treatment group and diet adjustment group. Lactulose group observed 1 week after the introduction period, the daily breakfast lactulose 15 ml taking a total of 3 weeks. Weekly follow-up 1, record stool frequency, traits, adverse reactions and assessment of efficacy. Results Patients with lactulose treatment experienced a rapid reduction in constipation symptoms within 3 days of starting medication. By the third week of treatment, 91% of patients in the lactulose treatment group were satisfied with the curative effect, while 35.5% of the patients in the dietary adjustment group were satisfied with the curative effect. The difference between the two groups was statistically significant. No significant adverse reactions were seen in both groups. Conclusion lactulose is an effective and safe drug for the treatment of chronic constipation in the elderly, which is suitable for wide application in primary hospitals.