论文部分内容阅读
目的评价不同剂量纳洛酮治疗新生儿呼吸衰竭的疗效。方法将 82例新生儿呼吸衰竭随机分为治疗Ⅰ组、治疗Ⅱ组和对照组。治疗Ⅰ组予小剂量纳洛酮 ,按每次 0 .0 1～ 0 .0 5mg kg静脉注射之后 ,以 0 .0 1～ 0 .0 2mg (kg·h)静脉滴注 ,维持 4～ 5小时 ,共 3～ 5天 ;治疗Ⅱ组按每次 0 .1mg kg静脉注射之后 ,继以 0 .0 3～ 0 .0 5mg (kg·h)静脉滴注维持 4～ 6小时 ,共 3～ 5天。对照组予常规综合治疗。比较 3组有效率和病死率。结果治疗Ⅰ组、治疗Ⅱ组和对照组总有效率分别为 74 .0 7%、93.10 %和 4 6 .15% ,病死率分别为 7.4 1%、6 .89%和 2 6 .92 %。结论纳洛酮治疗新生儿呼吸衰竭 ,能明显改善症状 ,提高有效率 ,降低病死率 ,大剂量组疗效明显优于小剂量组
Objective To evaluate the efficacy of different doses of naloxone in neonatal respiratory failure. Methods 82 cases of neonatal respiratory failure were randomly divided into treatment group Ⅰ, treatment Ⅱ group and control group. The patients in group Ⅰ were treated with naloxone at a low dose. After intravenous injection of 0,01-0.05 mg kg -1, intravenous infusion of 0,01-0.02 mg kg -1 was maintained for 4 to 5 days Hours, a total of 3 to 5 days; treatment Ⅱ group by 0.1 mg kg intravenous injection, followed by 0. 03 ~ 0. 05mg (kg · h) intravenous infusion for 4 to 6 hours, a total of 3 ~ 5 days. Control group to conventional comprehensive treatment. Comparison of three groups of efficiency and mortality. Results The total effective rates of treatment group Ⅰ, group Ⅱ and control group were 74.0%, 93.10% and 46.1% respectively, and the mortality rates were 7.41%, 6.89% and 26.62% respectively. Conclusion Naloxone treatment of neonatal respiratory failure, can significantly improve symptoms, improve efficiency and reduce mortality, the effect of high-dose group was significantly better than the low-dose group